Is rectus abdominis thickness associated with survival among patients with liver cirrhosis? A prospective cohort study
São Paulo med. j
; São Paulo med. j;137(5): 401-406, Sept.-Oct. 2019. tab, graf
Article
em En
| LILACS
| ID: biblio-1059101
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT BACKGROUND:
Sarcopenia may affect patients with liver cirrhosis and worsen disease outcomes.OBJECTIVES:
To evaluate ultrasound-measured psoas major (PM) and rectus abdominis (RA) thickness for predicting survival among patients with liver cirrhosis. DESIGN ANDSETTING:
Prospective cohort study in a tertiary-level hospital.METHODS:
61 patients with liver cirrhosis were prospectively included during a 15-month period and followed up for at least six months. Cirrhosis was classified using the Child-Pugh score. Sarcopenia was assessed using surrogate parameters handgrip strength (HGS), mid-arm muscle circumference (MAMC) and SGA (subjective global assessment). We used ultrasound to measure RA and PM thickness at admission.RESULTS:
There were 41 men. The patients' mean age was 58.03 ± 10.8 years. 26.22% of them were Child-Pugh A, 45.9% B and 27.86% C. The patients were followed up for 11.9 ± 5.63 months. RA thickness correlated moderately with MAMC (r = 0. 596; P < 0.0001) and HGS (r = 0.515; P < 0.0001) and decreased with increasing SGA class (A, 10.6 ± 2.8 mm; B, 8.3 ± 1.9 mm; C, 6.5 ± 1.9 mm; P < 0.0001). Survival at six months was independently predicted by using the model for end-stage liver disease-serum sodium score (odds ratio, OR 1.305; 95% OR confidence interval 1.083-1.572; P = 0.005). Survival during follow-up was independently predicted by RA thickness (hazard ratio, HR 0.701; 95% HR confidence interval 0.533-0.922; P = 0.011) and ascites (HR 1.876; 95% HR confidence interval 1.078-3.267; P = 0.026). PM thickness did not have any predictive value.CONCLUSIONS:
As a surrogate marker of sarcopenia, RA thickness may predict survival among patients with liver cirrhosis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Reto do Abdome
/
Sarcopenia
/
Cirrose Hepática
Tipo de estudo:
Etiology_studies
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
São Paulo med. j
Assunto da revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
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MEDICINA
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Romênia
País de publicação:
Brasil