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Polymorphism of Serotonin Transporter SLC6A4 (5-HTTLPR) Gene in Cheilitis Angularis Patients
Listyowati, Listyowati; Ismail, Raden Irawati; Partakusuma, Fatimah Boenjamin; Suhartono, Antonius Winoto; Auerkari, Elza Ibrahim.
Afiliação
  • Listyowati, Listyowati; University of Indonesia. Faculty of Dentistry. Department of Oral Biology. Jakarta. ID
  • Ismail, Raden Irawati; University of Indonesia. Faculty of Medicine. Department of Psychiatry. Jakarta. ID
  • Partakusuma, Fatimah Boenjamin; Trisakti University. Faculty of Dentistry. Department of Paediatric Dentistry. Jakarta. ID
  • Suhartono, Antonius Winoto; University of Indonesia. Faculty of Dentistry. Department of Oral Biology. Jakarta. ID
  • Auerkari, Elza Ibrahim; University of Indonesia. Faculty of Dentistry. Department of Oral Biology. Jakarta. ID
Pesqui. bras. odontopediatria clín. integr ; 19: e4874, 2019. tab, graf
Article em En | LILACS, BBO | ID: biblio-1056864
Biblioteca responsável: BR1264.1
ABSTRACT
Abstract

Objective:

To determine the relationship between the Serotonin transporter SLC6A4 (5-HTTLPR) gene polymorphism in cheilitis angularis patients. Material and

Methods:

We conducted a descriptive analysis of 100 DNA samples extracted from the blood serum of 50 patients with cheilitis angularis and 50 patients without cheilitis angularis. Analysis of the Serotonin transporter SLC6A4 (5-HTTLPR) gene polymorphism was observed by carrying out PCR method followed by electrophoresis for the analysis, without the usage of restriction enzyme. The Chi-square test was used for statistical analysis

Results:

In the cheilitis angularis group there were 24 samples with SS genotype, 23 samples with LS genotype, and 3 samples with LL genotype. Whereas in the non-cheilitis angularis group, there were 5 samples with SS genotype, 18 samples with LS genotype, and 27 samples with LL genotype. In the cheilitis angularis group found 71 S alleles and 29 L alleles, and in the non-cheilitis angularis group 28 S alleles and 72 L alleles were found. A statistically significant difference was found between the groups (p<0.001)

Conclusion:

There were significant differences in the distribution of the Serotonin transporter SLC6A4 (5-HTTLPR) gene polymorphism between patients with and without cheilitis angularis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: BBO / LILACS Assunto principal: Polimorfismo Genético / Proteínas da Membrana Plasmática de Transporte de Serotonina / Técnicas de Genotipagem / Genes Limite: Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Pesqui. bras. odontopediatria clín. integr Assunto da revista: ODONTOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Indonésia País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: BBO / LILACS Assunto principal: Polimorfismo Genético / Proteínas da Membrana Plasmática de Transporte de Serotonina / Técnicas de Genotipagem / Genes Limite: Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Pesqui. bras. odontopediatria clín. integr Assunto da revista: ODONTOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Indonésia País de publicação: Brasil