Your browser doesn't support javascript.
loading
Interleukin-6 in pregnancy with sickle cell disease
Costa, Manuela Freire Hazin; Torres, Leuridan Cavalcante; Matta, Marina Cadena da; Araújo, Aderson da Silva; Souza, Ariani Impieri.
Afiliação
  • Costa, Manuela Freire Hazin; Universidade Federal de Pernambuco - UFPE. Recife. BR
  • Torres, Leuridan Cavalcante; Instituto de Medicina Integral Prof. Fernando. Recife. BR
  • Matta, Marina Cadena da; Instituto de Medicina Integral Prof. Fernando. Recife. BR
  • Araújo, Aderson da Silva; Fundação de Hematologia e Hemoterapia de Pernambuco. Recife. BR
  • Souza, Ariani Impieri; Instituto de Medicina Integral Prof. Fernando. Recife. BR
Hematol., Transfus. Cell Ther. (Impr.) ; 41(4): 298-302, Oct.-Dec. 2019. tab, graf
Article em En | LILACS | ID: biblio-1056251
Biblioteca responsável: BR408.1
Localização: BR408.1
ABSTRACT
ABSTRACT

Background:

Despite advances in health care for sickle cell disease patients, as well as in the improvement in reproductive issues mainly in women with the disease, pregnancy is still a challenge, both for the mother and the child, with high rates of maternal and fetal morbidity and mortality. Besides their chronic hemolytic status and vaso-occlusive events that confer systemic complications, pregnant women also have higher rates of pain episodes, infections, abortion, intrauterine growth retardation, pre-term births, eclampsia, stillbirth and the hemolysis, elevated liver enzymes and low platelets syndrome. The physiologic mechanisms of the disease in pregnancy are still unknown and chronic inflammatory responses may interfere in the adverse outcomes. The cytokine and chemokine profiles in pregnancy with sickle cell disease remain unknown. The aim of this study was to evaluate the cytokine profile of the inflammatory response of pregnant women with sickle cell disease.

Method:

Blood samples from 20 pregnant women with sickle cell disease, 24 women with sickle cell disease in steady state, 16 healthy pregnant women and a control group with 9 women at childbearing age were assayed for interleukin-6. Main

results:

Pregnant women with sickle cell disease presented high serum levels of interleukin-6, compared to healthy pregnant women (p = 0.0115).

Conclusion:

These data suggest that the increased production of interleukin-6 may occur during pregnancy with sickle cell disease and that the role of this cytokine in the sickle cell disease pathophysiology and pregnancy complications should be further studied.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Gravidez / Citocinas / Interleucina-6 / Inflamação / Anemia Falciforme Limite: Adult / Female / Humans Idioma: En Revista: Hematol., Transfus. Cell Ther. (Impr.) Assunto da revista: Hematologia / TransfusÆo de Sangue Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Gravidez / Citocinas / Interleucina-6 / Inflamação / Anemia Falciforme Limite: Adult / Female / Humans Idioma: En Revista: Hematol., Transfus. Cell Ther. (Impr.) Assunto da revista: Hematologia / TransfusÆo de Sangue Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil