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Late onset systemic lupus erythematosus with severe hypercalcaemia / Lupus eritematoso sistémico de inicio tardío con hipercalcemia severa
Zhang, B; Yu, X; Mao, H; Xing, C; Liu, J.
Afiliação
  • Zhang, B; Nanjing Medical University. The First Affiliated Hospital. Department of Nephrology. Nanjing. CN
  • Yu, X; Nanjing Medical University. The First Affiliated Hospital. Department of Nephrology. Nanjing. CN
  • Mao, H; Nanjing Medical University. The First Affiliated Hospital. Department of Nephrology. Nanjing. CN
  • Xing, C; Nanjing Medical University. The First Affiliated Hospital. Department of Nephrology. Nanjing. CN
  • Liu, J; Nanjing Medical University. The First Affiliated Hospital. Department of Nephrology. Nanjing. CN
West Indian med. j ; West Indian med. j;62(1): 92-94, Jan. 2013. ilus, tab
Article em En | LILACS | ID: biblio-1045596
Biblioteca responsável: BR1.1
ABSTRACT
We report a case of a 76-year old female presenting with symptomatic severe hypercalcaemia, and subsequently diagnosed with late onset SLE due to the presence of anaemia, leucopenia, antibodies of antinuclear (ANA), anti-dsDNA, and also kidney impairment. Serum levels of FGF23 and intact-parathyroid hormone (iPTH) were low in this patient. Serum calcium, FGF23 and iPTH levels responded to steroids, which occurred simultaneously with disease activity. On follow-up, the faster increase in FGF23 than in parathyroid hormone suggested that FGF23 might be involved in the pathogenesis of hypercalcaemia in SLE.
RESUMEN
Se reporta el caso de una mujer de 76 años de edad que se presentó con hipercalcemia sintomática severa, y a la que posteriormente le fuera diagnosticada LES de inicio tardío con presencia de anemia, leucopenia, anticuerpos antinucleares (ANA), anti-dsDNA, e insuficiencia del riñón. Los niveles séricos del factor de crecimiento fibroblástico 23 (FGF23) y la hormona paratiroidea intacta (iPTH) fueron bajos en este paciente. Los niveles de calcio séricos, FGF23 e iPTH respondieron a los esteroides, que ocurrieron simultáneamente con la actividad de la enfermedad. En el seguimiento, el hecho de que el factor FGF23 aumentara más rápidamente que la hormona paratiroidea, sugiere que el FGF23 podría estar involucrado en la patogénesis de la hipercalcemia en LES.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Hipercalcemia / Lúpus Eritematoso Sistêmico Tipo de estudo: Diagnostic_studies Limite: Aged / Female / Humans Idioma: En Revista: West Indian med. j Assunto da revista: MEDICINA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China País de publicação: Jamaica
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Hipercalcemia / Lúpus Eritematoso Sistêmico Tipo de estudo: Diagnostic_studies Limite: Aged / Female / Humans Idioma: En Revista: West Indian med. j Assunto da revista: MEDICINA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China País de publicação: Jamaica