Hemofilia adquirida A y B como manifestación inicial de linfoma no Hodgkin. Reporte de un caso y revisión de la literatura / Acquired Hemophilia A and B as an initial manifestation of Non-Hodgkin Lymphoma. Case report and literature review
Rev. colomb. cancerol
; 23(3): 113-121, jul.-set. 2019. tab, graf
Article
em Es
| LILACS
| ID: biblio-1042763
Biblioteca responsável:
CO40.1
RESUMEN
Resumen La hemofilia adquirida es una complicación rara y potencialmente fatal en pacientes con neoplasias hematológicas (desórdenes linfoproliferativos) o tumores sólidos. Presentamos una paciente de 75 años de sexo femenino con antecedente de hipertensión arterial y anemia ferropénica que ingresa a urgencias por cuadro de dolor abdominal generalizado tipo cólico, asociado a episodios eméticos de contenido alimentario y deposiciones melénicas. Dentro de los estudios iniciales se encontraron tiempos de coagulación prolongados, prueba de mezclas de aPTT con evidencia de anticoagulante circulante específico, factor IX, 0% y factor VIII, 0% con inhibidores de factor VIII y IX en 180 UB y 130 UB respectivamente. Se consideró que la paciente cursaba con hemofilia adquirida A y B con realización de estudios de extensión diagnosticándose linfoma no Hodgkin marginal esplénico.
ABSTRACT
Abstract Acquired hemophilia is a potentially fatal rare complication of patients with hematological malignancies (usually lymphoproliferative disorders) or solid tumors. We report a 75-year female patient with a history of arterial hypertension and iron deficiency anemia. Log in to the emergency department complaining of generalized cramping abdominal pain associated with emetic episodes and melenic stools. In initial studies found prothrombin time (PT) 19 seconds control 11 seconds, INR 1.8 and activated partial thromboplastin time (aPTT) 45 seconds, control 29 seconds. Mixing aPTT study with normal plasma was performed suggesting specific anticoagulation factor. Other tests were performed Factor IX 0%, factor VIII and 0%. Factor VIII inhibitor 180 UB, factor IX inhibitor 130 UB. It was considered acquired hemophilia A and B and was studying with extension studies found a splenic marginal non Hodgkin lymphoma.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Linfoma não Hodgkin
/
Hemofilia B
/
Hemofilia A
Limite:
Aged
/
Female
/
Humans
Idioma:
Es
Revista:
Rev. colomb. cancerol
Assunto da revista:
Neoplasias
/
Oncologia
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Colômbia
País de publicação:
Colômbia