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Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
Ke, Yixin; Yu, Kaihang; Zeng, Weiliang; Lian, Guojun.
Afiliação
  • Ke, Yixin; Wenzhou Medical University. School of Laboratory Medicine and Life Science. Department of Health Inspection and Quarantine. Wenzhou. CN
  • Yu, Kaihang; Wenzhou Medical University. School of Laboratory Medicine and Life Science. Department of Health Inspection and Quarantine. Wenzhou. CN
  • Zeng, Weiliang; Wenzhou Medical University. School of Laboratory Medicine and Life Science. Department of Health Inspection and Quarantine. Wenzhou. CN
  • Lian, Guojun; Wenzhou Medical University. School of Laboratory Medicine and Life Science. Department of Health Inspection and Quarantine. Wenzhou. CN
Acta cir. bras ; Acta cir. bras;34(7): e201900706, 2019. tab, graf
Article em En | LILACS | ID: biblio-1038113
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Purpose:

To investigate the protective roles of pyracantha fortune fruit extract (PFE) on acute renal toxicity induced by cadmium chloride (CdCl2) in rats.

Methods:

Rats were pretreated with PFE and consecutively injected with CdCl2 (6.5 mg/kg) for 5 days.

Results:

The concentration of Cd, kidney weight, malondialdehyde (MDA), and nitric oxide (NO) production were remarkably increased in CdCl2 group as well as the levels of plasma uric acid, urea, and creatinine (P < 0.001). However, the body weight and glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione peroxidase (GR) levels were markedly reduced by CdCl2 treatment (P < 0.001). Histological manifestations of renal tissue showed severely adverse changes. Moreover, CdCl2 treatment significantly decreased the B-cell lymphoma-2 (Bcl-2) expression while increased the Bcl-2-Associated X Protein (Bax), tumor necrosis factor-α (TNF-α) expression (P < 0.001). Additionally, the expression of Nrf2/Keap 1 related proteins Keap-1 gained a significant increase (P < 0.001), whereas the Nrf2, HO-1, γ-GCS, GSH-Px and NQO1 expression decreased by CdCl2 treatment (P < 0.05). These rats were pretreated with PFE to improve the changes caused by CdCl2 treatment.

Conclusion:

PFE could protect the kidney against acute renal toxicity induced by CdCl2.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Extratos Vegetais / Cloreto de Cádmio / Pyracantha / Doença Hepática Induzida por Substâncias e Drogas / Rim / Antioxidantes Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Extratos Vegetais / Cloreto de Cádmio / Pyracantha / Doença Hepática Induzida por Substâncias e Drogas / Rim / Antioxidantes Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Brasil