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Intraoral EBV-positive sporadic Burkitt lymphoma in an elderly patient with bilateral presentation
Martínez Pedraza, Ricardo; Aristizabal Arboleda, Lady Paola; Sánchez-Romero, Celeste; Aguirre Quiñones, Jesús Alfonso; Mata Tovar, Carlos de Jesús; Rendón Henao, Javier; Almeida, Oslei Paes de.
Afiliação
  • Martínez Pedraza, Ricardo; Universidad Autónoma de Nuevo León. School of Dentistry. Department of Advance General Dental Master. Monterrey. MX
  • Aristizabal Arboleda, Lady Paola; University of Campinas. Piracicaba Dental School. Department of Oral Diagnosis. Piracicaba. BR
  • Sánchez-Romero, Celeste; University of Campinas. Piracicaba Dental School. Department of Oral Diagnosis. Piracicaba. BR
  • Aguirre Quiñones, Jesús Alfonso; Universidad Autónoma de Coahuila. School of Dentistry. Dental Sciences Master. Torreón. MX
  • Mata Tovar, Carlos de Jesús; Universidad Veracruzana. School of Dentistry. Forensic Medicine Master. Veracruz. MX
  • Rendón Henao, Javier; Universidad de Antioquia. Medical School. Medellín. CO
  • Almeida, Oslei Paes de; University of Campinas. Piracicaba Dental School. Department of Oral Diagnosis. Piracicaba. BR
Autops. Case Rep ; 9(4): e2019117, Oct.-Dec. 2019. ilus
Article em En | LILACS | ID: biblio-1024240
Biblioteca responsável: BR26.7
ABSTRACT
Sporadic Burkitt lymphoma (SBL) is a variant of Burkitt lymphoma that occurs worldwide, affecting mainly children and young adults. Association with Epstein-Barr virus (EBV) can be identified in approximately 20-30% of cases. Herein we described a case of a 63-year-old male presenting intraoral bilateral mandibular swelling, subjacent to fixed dental prosthesis, with one month of duration. Incisional biopsies were performed, and after two days, the patient was hospitalized due to malaise and breathing difficulty, and died after a week when an abdominal tumor was detected. The mandibular biopsies revealed a diffuse proliferation of medium-sized monomorphic atypical lymphoid cells exhibiting numerous mitoses and areas of "starry-sky" pattern. The tumor showed immunohistochemical positivity for CD20, CD10, Bcl-6, and Ki-67 (≈ 100%); it was negative for CD3, Bcl-2, Vs38c, and MUM-1. Positivity for EBV was found by in situ hybridization. The final diagnosis was intraoral SBL positive for EBV. Clinical, morphological and molecular criteria are necessary for the correct diagnosis of aggressive B-cell neoplasms positive for EBV in elderly patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias Bucais / Linfoma de Burkitt / Herpesvirus Humano 4 Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Revista: Autops. Case Rep Assunto da revista: Anatomia / Patologia Cl¡nica / Patologia Legal Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil / Colômbia / México País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias Bucais / Linfoma de Burkitt / Herpesvirus Humano 4 Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Revista: Autops. Case Rep Assunto da revista: Anatomia / Patologia Cl¡nica / Patologia Legal Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil / Colômbia / México País de publicação: Brasil