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Intestinal microbiota changes after solid organ transplantation: a systematic review
Forte, Cristina Carra; Pedrollo, Elis Forcellini; Souza, Gabriela Corrêa; Leitão, Cristiane Bauermann.
Afiliação
  • Forte, Cristina Carra; Universidade Federal do Rio Grande do Sul (UFRGS). Programa de Pós-Graduação em Ciências Médicas: Endocrinologia. Porto Alegre. BR
  • Pedrollo, Elis Forcellini; Universidade Federal do Rio Grande do Sul (UFRGS). Programa de Pós-Graduação em Ciências Médicas: Endocrinologia. Porto Alegre. BR
  • Souza, Gabriela Corrêa; Universidade Federal do Rio Grande do Sul (UFRGS). Faculdade de Medicina. Departamento de Nutrição. Porto Alegre. BR
  • Leitão, Cristiane Bauermann; Universidade Federal do Rio Grande do Sul (UFRGS). Programa de Pós-Graduação em Ciências Médicas: Endocrinologia. BR
Clin. biomed. res ; 38(1): 87-92, 2018.
Article em En | LILACS | ID: biblio-1022449
Biblioteca responsável: BR18.1
ABSTRACT

Introduction:

The intestinal microbiota may undergo changes after solid organ transplantation. The purpose of this systematic review was to characterize the intestinal microbiota of patients undergoing solid organ transplantation.

Methods:

MEDLINE, EMBASE and Cochrane Library databases were searched from inception to July 21, 2017. Studies of patients undergoing solid organ transplantation that evaluated changes in intestinal microbiota composition and one of the following outcomes were included post-transplant weight, new-onset diabetes after transplantation, delayed graft function, acute rejection, graft and patient survival, and post-transplant infections.

Results:

Out of 765 studies found in this search, two studies (86 patients) fulfilled inclusion criteria. Both studies assessed kidney transplantation recipients, and a reduction in bacterial species diversity after transplantation was observed. Changes in intestinal microbiota were associated with acute rejection in both studies. One study reported diarrhea and urinary infections, while the other one reported urinary and respiratory infections. None of them reported other outcomes of interest.

Conclusion:

Changes in intestinal microbiota were observed after kidney transplantation, and they were associated with higher incidence of acute rejection and infections in transplant recipients. However, data are still scarce and more studies are needed to evaluate if microbiota changes have an impact on post-transplant outcomes. (AU)
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Transplante de Rim / Transplantes / Microbioma Gastrointestinal Tipo de estudo: Systematic_reviews Limite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Clin. biomed. res Assunto da revista: MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Transplante de Rim / Transplantes / Microbioma Gastrointestinal Tipo de estudo: Systematic_reviews Limite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Clin. biomed. res Assunto da revista: MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil