Factors associated with mortality in HIV patients failing antiretroviral therapy, in Salvador, Brazil

Haguihara, Tatiana; Silva, Márcio da Oliveira; Rebouças, Monaliza Cardozo; Martins Netto, Eduardo; Brites, Carlos

Haguihara, Tatiana; Silva, Márcio da Oliveira; Rebouças, Monaliza Cardozo; Martins Netto, Eduardo; Brites, Carlos.

Afiliação

Haguihara, Tatiana; Specialized Center for Diagnosis. Assistance and Research. Department of Health of the State of Bahia. Salvador. BR
Silva, Márcio da Oliveira; Specialized Center for Diagnosis. Assistance and Research. Department of Health of the State of Bahia. Salvador. BR
Rebouças, Monaliza Cardozo; Specialized Center for Diagnosis. Assistance and Research. Department of Health of the State of Bahia. Salvador. BR
Martins Netto, Eduardo; Federal University of Bahia. Post-graduation Program in Medicine and Health. Salvador. BR
Brites, Carlos; Federal University of Bahia. Post-graduation Program in Medicine and Health. Salvador. BR

Braz. j. infect. dis ; Braz. j. infect. dis;23(3): 160-163, May-June 2019. tab, graf

Article em En | LILACS | ID: biblio-1019550

Biblioteca responsável: BR1.1

ABSTRACT

ABSTRACT

ABSTRACT Highly active antiretroviral therapy (HAART) has significantly improved survival of people living with HIV/Aids (PLWHA). However, poor treatment adherence to HAART and other problems, still cause therapy failure and contribute to increased morbidity and mortality of PLWHA. In this retrospective cohort study (2013-2015), we sought to evaluate the factors associated with mortality of PLWHA failing HAART in 2013, who were receiving care at a reference center for sexually transmitted diseases (STD) and HIV/AIDS. A total of 165 individuals over 18 years of age who were failing antiretroviral therapy were evaluated. In two-year follow-up, 19 (11.5%) deaths were documented. There were a significant association between mortality and report of illicit drug use (53%, p < 0.01), being attended by a larger number of medical professionals (6.3 ± 3.2, p = 0.02), use of firstline non-nucleoside reverse transcriptase inhibitor (74%, p = 0.01), and history of interrupting HAART ≥3 months (90%), p = 0.02). Patients who died had a significantly higher viral load (mean 49,192.4 ± 35,783.6 copies/mL) than survivors (26,389.2 ± 27,416 copies/mm3, p < 0.01), lower mean CD4 cell counts (127.8 ± 145.6 cells/mm3 vs. 303.3 ± 202.4 cells/mm3, p < 0.01), and higher frequency of previous virologic failure (89% vs. 74.7%, p < 0.01). Our results reinforce the importance of early detection and prevention of virologic failure, to reduce the mortality associated with this event.

Assuntos

Humanos; Masculino; Feminino; Adulto; Infecções por HIV/mortalidade; Terapia Antirretroviral de Alta Atividade; Brasil/epidemiologia; Infecções por HIV/tratamento farmacológico; Estudos Retrospectivos; Fatores de Risco; Estudos de Coortes; Falha de Tratamento; Contagem de Linfócito CD4; Carga Viral

Palavras-chave

HIV; Mortality; Virologic failure

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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Infecções por HIV / Terapia Antirretroviral de Alta Atividade Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies / Screening_studies Limite: Adult / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

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