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Chloroquine: an old drug with new perspective against giardiasis
Escobedo, Angel A; Almirall, Pedro; Cimerman, Sergio; Lalle, Marco; Pacheco, Frank; Acanda, Carlos Z; Sanchez, Niurka.
Afiliação
  • Escobedo, Angel A; Paediatric Academic Hospital "Pedro Borras". Havana. CU
  • Almirall, Pedro; Municipal Centre of Hygiene, Epidemiology and Microbiology. Havana. CU
  • Cimerman, Sergio; Secretaria de Estado da Saúde. São Paulo. Instituto de Infectologia Emilio Ribas. São Paulo. BR
  • Lalle, Marco; Istituto Superiore di Sanità. Roma. IT
  • Pacheco, Frank; Polyclinic Cerro. Havana. CU
  • Acanda, Carlos Z; Cuban Institute of Gastro-enterology. Havana. CU
  • Sanchez, Niurka; Cuban Institute of Gastro-enterology. Havana. CU
Recent pat. antiinfect. drug discov ; 10(2): 134-141, 2015. ilus, tab
Article em En | SES-SP, SESSP-IIERPROD, SES-SP | ID: biblio-1016860
Biblioteca responsável: BR31.1
Localização: BR31.1; 2015_P-032
ABSTRACT
The occurrence of treatment failures to first-line treatment for giardiasis, one of the most widespread although neglected parasitic disease, has long been recognised. Nowadays, it starts to represent a great challenge to clinicians, especially in endemic countries. This requires the introduction of new drug interventions, but the development of novel drugs is a time and money consuming effort with most of the compounds never reaching the market. Consequently, alternative strategies are needed, especially for the treatment of giardiasis. Chloroquine (CQ), a synthetic drug developed as antimalarial agent, has been shown to also exert antigiardial activity. Here, we present a mini-research summarizing results on the treatment of human clinical cases with CQ, going through in vitro research, case report, and case series to human clinical trials, highlighting the benefits and mentioning possible adverse effects
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Texto completo: 1 Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IIERPROD Assunto principal: Cloroquina / Giardíase Limite: Aged / Child / Female / Humans Idioma: En Revista: Recent pat. antiinfect. drug discov Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IIERPROD Assunto principal: Cloroquina / Giardíase Limite: Aged / Child / Female / Humans Idioma: En Revista: Recent pat. antiinfect. drug discov Ano de publicação: 2015 Tipo de documento: Article