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Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial
Ashton, Melanie M; Berk, Michael; Ng, Chee H; Hopwood, Malcolm; Dodd, Seetal; Turner, Alyna; Brown, Ellie; Jacka, Felice N; Cotton, Susan M; Khoo, Jon-Paul; Chatterton, Mary Lou; Kavanagh, Bianca E; Nadjidai, Sarah E; Lo Monaco, Samantha L; Harvey, Brian H; Sarris, Jerome; Malhi, Gin S; Dowling, Nathan L; Dean, Olivia M.
Afiliação
  • Ashton, Melanie M; School of Medicine. Deakin University, Innovation in Mental and Physical Health and Clinical Treatment (IMPACT) Strategic Research Centre. Geelong. AU
  • Berk, Michael; School of Medicine. Deakin University, Innovation in Mental and Physical Health and Clinical Treatment (IMPACT) Strategic Research Centre. Geelong. AU
  • Ng, Chee H; University of Melbourne. The Melbourne Clinic. Department of Psychiatry. AU
  • Hopwood, Malcolm; University of Melbourne. Florey Institute for Neuroscience and Mental Health. AU
  • Dodd, Seetal; School of Medicine. Deakin University, Innovation in Mental and Physical Health and Clinical Treatment (IMPACT) Strategic Research Centre. Geelong. AU
  • Turner, Alyna; School of Medicine. Deakin University, Innovation in Mental and Physical Health and Clinical Treatment (IMPACT) Strategic Research Centre. Geelong. AU
  • Brown, Ellie; School of Medicine. Deakin University, Innovation in Mental and Physical Health and Clinical Treatment (IMPACT) Strategic Research Centre. Geelong. AU
  • Jacka, Felice N; School of Medicine. Deakin University, Innovation in Mental and Physical Health and Clinical Treatment (IMPACT) Strategic Research Centre. Geelong. AU
  • Cotton, Susan M; National Centre of Excellence in Youth Mental Health. Orygen. AU
  • Khoo, Jon-Paul; School of Medicine. Deakin University, Innovation in Mental and Physical Health and Clinical Treatment (IMPACT) Strategic Research Centre. Geelong. AU
  • Chatterton, Mary Lou; Deakin University. Deakin Health Economics. Centre for Population Health Research. AU
  • Kavanagh, Bianca E; School of Medicine. Deakin University, Innovation in Mental and Physical Health and Clinical Treatment (IMPACT) Strategic Research Centre. Geelong. AU
  • Nadjidai, Sarah E; University of Melbourne. The Melbourne Clinic. Department of Psychiatry. AU
  • Lo Monaco, Samantha L; School of Medicine. Deakin University, Innovation in Mental and Physical Health and Clinical Treatment (IMPACT) Strategic Research Centre. Geelong. AU
  • Harvey, Brian H; North-West University. School of Pharmacy. Center of Excellence for Pharmaceutical Sciences. ZA
  • Sarris, Jerome; University of Melbourne. The Melbourne Clinic. Department of Psychiatry. AU
  • Malhi, Gin S; Academic Department of Psychiatry. St. Leonards. AU
  • Dowling, Nathan L; University of Melbourne. The Melbourne Clinic. Department of Psychiatry. AU
  • Dean, Olivia M; School of Medicine. Deakin University, Innovation in Mental and Physical Health and Clinical Treatment (IMPACT) Strategic Research Centre. Geelong. AU
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; Braz. J. Psychiatry (São Paulo, 1999, Impr.);41(3): 245-253, May-June 2019. tab
Article em En | LILACS | ID: biblio-1011490
Biblioteca responsável: BR1.1
ABSTRACT

Objective:

Bipolar depression is characterized by neurobiological features including perturbed oxidative biology, reduction in antioxidant levels, and a concomitant rise in oxidative stress markers. Bipolar depression manifests systemic inflammation, mitochondrial dysfunction, and changes in brain growth factors. The depressive phase of the disorder is the most common and responds the least to conventional treatments. Garcinia mangostana Linn, commonly known as mangosteen, is a tropical fruit. The pericarp's properties may reduce oxidative stress and inflammation and improve neurogenesis, making mangosteen pericarp a promising add-on therapy for bipolar depression.

Methods:

Participants will receive 24 weeks of either 1,000 mg mangosteen pericarp or placebo per day, in addition to their usual treatment. The primary outcome is change in severity of mood symptoms, measured using the Montgomery-Åsberg Depression Rating Scale (MADRS), over the treatment phase. Secondary outcomes include global psychopathology, quality of life, functioning, substance use, cognition, safety, biological data, and cost-effectiveness. A follow-up interview will be conducted 4 weeks post-treatment.

Conclusion:

The findings of this study may have implications for improving treatment outcomes for those with bipolar disorder and may contribute to our understanding of the pathophysiology of bipolar depression. Clinical trial registration Australian and New Zealand Clinical Trial Registry, ACTRN12616000028404.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Transtorno Bipolar / Garcinia mangostana / Transtorno Depressivo / Frutas / Antioxidantes Tipo de estudo: Clinical_trials Aspecto: Patient_preference Limite: Humans País/Região como assunto: Oceania Idioma: En Revista: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Assunto da revista: PSIQUIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Austrália / África do Sul País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Transtorno Bipolar / Garcinia mangostana / Transtorno Depressivo / Frutas / Antioxidantes Tipo de estudo: Clinical_trials Aspecto: Patient_preference Limite: Humans País/Região como assunto: Oceania Idioma: En Revista: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Assunto da revista: PSIQUIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Austrália / África do Sul País de publicação: Brasil