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Aporphine alkaloids from Piper erecticaule and acetylcholinesterase inhibitory activity / Alcaloides de aporfina obtenida de Piper erecticaule y actividad inhibitoria de la acetilcolinesterasa
Salleh, Wan Mohd Nuzul Hakimi Wan; Abdullah, Norkamilah; Hashim, Nur Athirah; Khong, Heng Yen; Khamis, Shamsul.
Afiliação
  • Salleh, Wan Mohd Nuzul Hakimi Wan; Universiti Pendidikan Sultan Idris. Faculty of Sciences and Mathematics. Department of Chemistry. MY
  • Abdullah, Norkamilah; Universiti Pendidikan Sultan Idris. Faculty of Sciences and Mathematics. Department of Chemistry. MY
  • Hashim, Nur Athirah; Universiti Teknologi Malaysia. Faculty of Science. Department of Chemistry. MY
  • Khong, Heng Yen; Universiti Teknologi MARA. Faculty of Applied Sciences. School of Chemistry and Environment Studies. MY
  • Khamis, Shamsul; Universiti Kebangsaan Malaysia. Faculty of Science and Technology. School of Environmental and Natural Sciences. MY
Bol. latinoam. Caribe plantas med. aromát ; 18(5): 527-532, sept. 2019. ilus, tab
Article em En | LILACS | ID: biblio-1008292
Biblioteca responsável: CL1.1
ABSTRACT
Chemical constituents and biological activities of the aerial parts of Piper erecticaule C.DC. have been studied for the first time. Fractionation and purification of the extracts afforded aristolactam AII (1), aristolactam BII (2), piperolactam A (3), piperolactam C (4), piperolactam D (5), together with terpenoids of ß-sitosterol, ß-sitostenone, taraxerol, and lupeol. The structures of these compounds were obtained by analysis of their spectroscopic data, as well as the comparison with that of reported data. Acetylcholinesterase inhibitory activity revealed that compounds 1 and 3 showed strong AChE inhibitory effects with the percentage inhibition of 75.8% and 74.8%, respectively.
RESUMEN
Se estudiaron por primera vez los constituyentes químicos y actividad biológica de las partes aéreas de Piper erecticaule C.DC. El fraccionamiento y la purificación de los extractos proporcionaron aristolactama AII (1), aristolactama BII (2), piperolactama A (3), piperolactama C (4), piperolactama D (5), junto con terpenoides de ß-sitosterol, ß-sitostenona, taraxerol, y el lupeol. Las estructuras de estos compuestos se obtuvieron mediante el análisis de sus datos espectroscópicos, así como mediante la comparación con datos ya informados. La actividad inhibidora de la acetilcolinesterasa reveló que los compuestos 1 y 3 mostraron un potente efecto inhibidor de la AChE con un porcentaje de inhibición del 75.8% y 74.8%, respectivamente.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Aporfinas / Acetilcolinesterase / Extratos Vegetais / Inibidores da Colinesterase / Piper / Alcaloides Idioma: En Revista: Bol. latinoam. Caribe plantas med. aromát Assunto da revista: BOTANICA / MEDICINA / Plantas Medicinais / Terapias Complementares Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Malásia País de publicação: Chile
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Aporfinas / Acetilcolinesterase / Extratos Vegetais / Inibidores da Colinesterase / Piper / Alcaloides Idioma: En Revista: Bol. latinoam. Caribe plantas med. aromát Assunto da revista: BOTANICA / MEDICINA / Plantas Medicinais / Terapias Complementares Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Malásia País de publicação: Chile