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Fulvestrant-induced toxic epidermal necrolysis
Morales-Conde, Macarena; López-Ibáñez, Natividad; Calvete-Candenas, Julio; Mendonça, Francisco Manuel Ildefonso.
Afiliação
  • Morales-Conde, Macarena; University Hospital Virgen Macarena. Department of Dermatology. Seville. ES
  • López-Ibáñez, Natividad; University Hospital Virgen Macarena. Department of Dermatology. Seville. ES
  • Calvete-Candenas, Julio; University Hospital Virgen Macarena. Department of Oncology. Seville. ES
  • Mendonça, Francisco Manuel Ildefonso; University Hospital Virgen Macarena. Department of Dermatology. Seville. ES
An. bras. dermatol ; An. bras. dermatol;94(2): 218-220, Mar.-Apr. 2019. tab, graf
Article em En | LILACS | ID: biblio-1001152
Biblioteca responsável: BR1.1
ABSTRACT
Abstract Toxic epidermal necrolysis is a condition with massive keratinocyte apoptosis, and it is associated with high mortality rates. Fulvestrant, an estrogen receptor antagonist, is indicated in the treatment of estrogen receptor-positive metastatic breast cancer in postmenopausal women. To our knowledge, this is the first described case of toxic epidermal necrolysis due to fulvestrant. A 56-year-old woman received 500 mg of intramuscular fulvestrant monthly for metastatic ductal carcinoma of the breast. Five days after the first dose, the patient presented with a maculopapular rash that evolved to blisters, and a detachment of the epidermis in over 30% of the total body surface area. Histological analysis was compatible with toxic epidermal necrolysis. Fulvestrant was discontinued, topical management and supportive care were initiated.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Pele / Síndrome de Stevens-Johnson / Antagonistas do Receptor de Estrogênio / Fulvestranto Limite: Female / Humans Idioma: En Revista: An. bras. dermatol Assunto da revista: DERMATOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Espanha País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Pele / Síndrome de Stevens-Johnson / Antagonistas do Receptor de Estrogênio / Fulvestranto Limite: Female / Humans Idioma: En Revista: An. bras. dermatol Assunto da revista: DERMATOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Espanha País de publicação: Brasil