Neutrophil elastase:From mechanisms to therapeutic potential / 药物分析学报
Journal of Pharmaceutical Analysis
; (6): 355-366, 2023.
Article
en Zh
| WPRIM
| ID: wpr-991149
Biblioteca responsable:
WPRO
ABSTRACT
Neutrophil elastase(NE),a major protease in the primary granules of neutrophils,is involved in microbicidal activity.NE is an important factor promoting inflammation,has bactericidal effects,and shortens the inflammatory process.NE also regulates tumor growth by promoting metastasis and tumor microenvironment remodeling.However,NE plays a role in killing tumors under certain conditions and promotes other diseases such as pulmonary ventilation dysfunction.Additionally,it plays a complex role in various physiological processes and mediates several diseases.Sivelestat,a specific NE inhibitor,has strong potential for clinical application,particularly in the treatment of coronavirus disease 2019(COVID-19).This review discusses the pathophysiological processes associated with NE and the potential clinical applications of sivelestat.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of Pharmaceutical Analysis
Año:
2023
Tipo del documento:
Article