Anti-inflammatory effects of Houttuynia cordata supercritical extract in carrageenan-air pouch inflammation model / 한국실험동물학회지
Laboratory Animal Research
; : 137-140, 2012.
Article
en En
| WPRIM
| ID: wpr-98976
Biblioteca responsable:
WPRO
ABSTRACT
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in rat carrageenan-air pouch model. Oral administration of HSE (50-200 mg/kg) suppressed carrageenan-induced exudation and albumin leakage, as well as inflammatory cell infiltration at a high dose (200 mg/kg). Intraperitoneal injection of dexamethasone (2 mg/kg) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content without influence on the cell number. HSE lowered tumor-necrosis factor-alpha (TNF-alpha) and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-alpha and NO, while indomethacin decreased PGE2. The results indicate that HSE exhibits anti-inflammatory effects by inhibiting both TNF-alpha-NO and cyclooxygenase-2-PGE2 pathways.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Dexametasona
/
Dinoprostona
/
Carragenina
/
Recuento de Células
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Indometacina
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Administración Oral
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Factor de Necrosis Tumoral alfa
/
Houttuynia
/
Exudados y Transudados
/
Inflamación
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Laboratory Animal Research
Año:
2012
Tipo del documento:
Article