Reaserch progress of microglial phagocytosis in ischemic stroke / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 399-409, 2023.
Article
en Zh
| WPRIM
| ID: wpr-987659
Biblioteca responsable:
WPRO
ABSTRACT
@#Ischemic stroke is a major disease affecting human health, and its pathological mechanism has not been fully elucidated. Microglia are important immune cells in the central nervous system, and participate in the pathological process of ischemic stroke.Following an ischemic stroke, a surge in activated microglia occurs, migrating and congregating within the afflicted regions.These microglia engulf deceased cells or fragments, releasing inflammatory or nutritive factors, thereby participating in the pathogenesis of ischemic stroke.The phagocytosis of microglia plays an important role in cerebral ischemic injury and rehabilitation. This article summarizes the molecular mechanism of microglial phagocytosis and reviews the research progress of microglial phagocytosis in ischemic stroke, and discusses the diversity and complexity of microglial phagocytosis in cerebral ischemic injury and rehabilitation, so as to provide new ideas for the treatment and drug development of ischemic stroke.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of China Pharmaceutical University
Año:
2023
Tipo del documento:
Article