Effects of ketamine and alcohol on learning and memory impairment in mice / 法医学杂志
Journal of Forensic Medicine
; (6): 115-119, 2012.
Article
en Zh
| WPRIM
| ID: wpr-983724
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To study the effects of ketamine and alcohol on learning and memory in mice and its possible mechanism.@*METHODS@#Forty mice were divided into 4 groups: normal control group, ketamine group, alcohol group, and alcohol plus ketamine group. Ketamine and alcohol were given by intraperitoneal injection and intragastric administration, respectively, 1 time per day, for 14 days. The ability of learning and memory in mice was tested by the method of step-down and Morris water maze. Acetylcholine (ACh) and 5-hydroxy tryptamine(5-HT) in mice brain tissue were analyzed for the possible mechanism.@*RESULTS@#(1) Step-down: The treatment groups lessened the latency and added wrong times (P < 0.05). The number of errors in the combined treatment group significantly increased comparing with the single drug treatment group (P < 0.05). (2) Morris water-maze: The treatment groups prolonged the latency (P < 0.05), reduced the target quadrant activity time significantly (P < 0.05), and decreased the numbers of crossing the former platform significantly (P < 0.05). (3) Biochemical index determination: The concentrations of ACh and 5-HT in treatment groups decreased significantly (P < 0.05), showed a more decreasement comparing with the single drug treatment group.@*CONCLUSION@#Ketamine has a synergistic effect with alcohol on learning and memory impairment in mice, which may be related to the common inhibitive effect on the ACh and 5-HT.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Conducta Espacial
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Encéfalo
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Acetilcolina
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Serotonina
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Aprendizaje por Laberinto
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Alcoholes
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Sinergismo Farmacológico
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Ketamina
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Memoria
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Trastornos de la Memoria
Límite:
Animals
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Año:
2012
Tipo del documento:
Article