Expression of CAR in myocardial of viral myocarditis and dilated cardiomyopathy / 法医学杂志
Journal of Forensic Medicine
; (6): 328-331, 2010.
Article
en Zh
| WPRIM
| ID: wpr-983588
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#In order to improve accuracy and reliability of forensic diagnosis of sudden cardiac death, pathogenesis and relationship between the viral myocarditis (VMC) and dilated cardiomyopathy (DCM) were investigated.@*METHODS@#Improved immunohistochemical technique was used to detect the expression of the CAR in myocardium samples, including 22 deceased with VMC, 20 deceased with DCM and 16 control deceased.@*RESULTS@#The brown staining on the cell membrane of myocardium showed positive result. There was a prominent CAR expression in VMC group and DCM group, which were statistically significant difference compared with control group (P < 0.05).@*CONCLUSION@#The CAR expression showed significantly higher in VMC and DCM groups. The viral infection can result in myocardial necrosis and impaired cardiac functions. These abnormalities can trigger a cascade of events that contributed to the progress of VMC to DCM.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Receptores Virales
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Coloración y Etiquetado
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Inmunohistoquímica
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Cardiomiopatía Dilatada
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Estudios de Casos y Controles
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Muerte Súbita Cardíaca
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Infecciones por Coxsackievirus
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Patologia Forense
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Proteína de la Membrana Similar al Receptor de Coxsackie y Adenovirus
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Miocarditis
Límite:
Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Año:
2010
Tipo del documento:
Article