Advances in research of ketamine addiction mechanism / 法医学杂志
Journal of Forensic Medicine
; (6): 200-207, 2009.
Article
en Zh
| WPRIM
| ID: wpr-983474
Biblioteca responsable:
WPRO
ABSTRACT
Ketamine is a phencyclidine derivative acting primarily as a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) excitatory glutamate receptors. As a common intravenous anaesthetic in clinic, it is also increasingly abused because of its hallucination and addiction effects. Based on the pharmacological and toxicologic characteristics of ketamine and the acknowledged addiction mechanism of other abused drugs, this article reviews the possible addiction mechanism of the ketamine in the aspects of its enhanced effects and reward systems, the anatomic structures, the related receptors and the individual differences.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Encéfalo
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Drogas Ilícitas
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Receptores Dopaminérgicos
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Receptores de N-Metil-D-Aspartato
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Trastornos Relacionados con Sustancias
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Ketamina
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Anestésicos Disociativos
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Trastornos Mentales
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Año:
2009
Tipo del documento:
Article