Changes of phospho-JNK expression during the skin burned wound healing / 法医学杂志
Journal of Forensic Medicine
; (6): 325-335, 2008.
Article
en Zh
| WPRIM
| ID: wpr-983402
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To observe the changes of expression of phosphorylation c-Jun NH2-terminal kinase (p-JNK) during the skin burned wound healing in patients and discuss the molecular mechanism of burned wound healing.@*METHODS@#The staining intensity and distribution of p-JNK were detected by immunohistochemistry and routine histology in burned skin samples of 12 patients and normal skin samples of 12 control subjects.@*RESULTS@#In normal skin, the positive signals of p-JNK were mostly localized in basal layer cells of the epidermis, with a positive rate of (8.8+/-1.3)%. In the burned group, the positive signals of p-JNK were mainly localized in the epidermal cells and some inflammatory cells, with a significantly higher positive rate of (31.2+/-3.3)% than the normal group(P<0.01).@*CONCLUSION@#The changes of p-JNK expression after skin burned might correlate with wound healing.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fosforilación
/
Piel
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Cicatrización de Heridas
/
Quemaduras
/
Distribución Aleatoria
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Proteínas Quinasas JNK Activadas por Mitógenos
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Medicina Legal
Límite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Año:
2008
Tipo del documento:
Article