Notch signaling regulates macrophages during inflammation and infection: An update / 细胞与分子免疫学杂志
Chinese Journal of Cellular and Molecular Immunology
; (12): 468-473, 2023.
Article
en Zh
| WPRIM
| ID: wpr-981887
Biblioteca responsable:
WPRO
ABSTRACT
Macrophage as a crucial component of innate immunity, plays an important role in inflammation and infection immunity. Notch signal pathway is a highly conserved pathway, which regulates cellular fate and participates in numerous pathological processes. At present, a lot of literature has confirmed the role of Notch signaling in regulating the differentiation, activation and metabolism of macrophage during inflammation and infection. This review focuses on how Notch signaling promotes macrophage pro-inflammatory and anti-infective immune function in different inflammatory and infectious diseases. In this regulation, Notch signaling interact with TLR signaling in macrophages or inflammatory-related cytokines including IL-6, IL-12, and TNF-α. Additionally, the potential application and challenges of Notch signaling as a therapeutic target against inflammation and infectious diseases are also discussed.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Transducción de Señal
/
Enfermedades Transmisibles
/
Citocinas
/
Receptores Notch
/
Inflamación
/
Macrófagos
Límite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Cellular and Molecular Immunology
Año:
2023
Tipo del documento:
Article