Advances in potential drugs for improvement of energy metabolism in heart failure / 药学实践与服务
Journal of Pharmaceutical Practice and Service
; (12): 284-290, 2023.
Article
en Zh
| WPRIM
| ID: wpr-973685
Biblioteca responsable:
WPRO
ABSTRACT
Heart failure (HF) is a global public health problem with high morbidity and mortality. Numerous studies have shown that HF is caused by severe disturbance of energy metabolism, resulting in insufficient cardiac energy supply. This lack of energy could lead to a failure of the heart to pump blood and a failure of energy metabolism in other organs throughout the body. Currently, therapeutics of HF work by reducing heart rate and cardiac preload and afterload, symptomatic treatment, or delaying the progression of the disease. However, drugs targeting heart energy metabolism have not been developed. the main characteristics of cardiac energy metabolism, metabolic changes during HF were summarized and drugs that improve cardiac function through energy metabolism were discussed, which could provide a new research direction for the development and application of drugs in treatment of heart failure.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of Pharmaceutical Practice and Service
Año:
2023
Tipo del documento:
Article