Glypican-3-specific cytotoxic T lymphocytes induced by human leucocyte antigen-A*0201-restricted peptide effectively kill hepatocellular carcinoma cells in vitro
Asian Pacific Journal of Tropical Medicine
; (12): 1084-1089, 2017.
Article
en Zh
| WPRIM
| ID: wpr-972537
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate potential human leucocyte antigen (HLA)-A2-restricted epitope peptides of glypican-3 (GPC3) and determine the cytotoxicity of peptide-specific cytotoxic T lymphocytes (CTLs) against hepatocellular carcinoma (HCC) cells. Methods The potential HLA-A*0201-restricted GPC3 peptides were screened using computer algorithms, T2 cell-binding affinity and stability of peptide/HLA-A*0201 complex assay. The peptide-specific CTLs were generated and their cytotoxicity against GPC3
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2017
Tipo del documento:
Article