Lidocaine as a diluent for Benzathine Penicillin G for injection pain in children with rheumatic fever and rheumatic heart disease: A randomized double-blind crossover study
The Philippine Children&rsquo
; s Medical Center Journal;(2): 64-74, 2018.
Article
en En
| WPRIM
| ID: wpr-960210
Biblioteca responsable:
WPRO
ABSTRACT
@#<p style="text-align: justify;"><strong>BACKGROUND</strong>: Rheumatic fever (RF) and Rheumatic heart disease (RHD) patients Rheumatic Heart Disease (RHD) patients necessitate secondary prophylaxis with benzathine penicillin G (BPG) injection every 3 weeks to prevent recurrences and complications. Patients with rheumatic fever on regular benzathine penicillin G injection usually experience moderate to severe pain resulting to poor compliance to treatment. </p><p style="text-align: justify;"><strong>OBJECTIVES:</strong> This study aims to compare the effect of BPG diluted in lidocaine hydrochloride 1% versus diluted water in reducing injection pain in patients with RF and RHD.</p><p style="text-align: justify;"><strong>METHODS</strong>: This is a randomized double-blind crossover study conducted at the PCMC OPD. Thirty-three patients diagnosed with RF and RHD were divided into 2 groups; the first group received BPG diluted in sterile water followed by BPG diluted in lidocaine hydrochloride 1% after 21 days, the second group received the same medication in reverse order. Pain scale was measured using Universal pain assessment tool immediately after injection. Paired T test was used to compare the pain score results of the two groups.</p><p style="text-align: justify;"><strong>RESULTS:</strong> Pain score was significantly less in patients who received BPG diluted in lidocaine hydrochloride 1%; from an average pain score of 4.88 to 0.63 (p<0.0001), among those who received BPG diluted in sterile water. No adverse effects were seen in all patients.</p><p style="text-align: justify;"><strong>CONCLUSION:</strong> This study concluded that BPG diluted in lidocaine hydrochloride 1% significantly and safely reduced post-injection pain. In all patients diagnosed with RF and RHD, BPG injection should be diluted in lidocaine hydrochloride 1% to decrease injection pain and improve patient's compliance.</p>
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Dolor
/
Penicilina G Benzatina
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Penicilinas
/
Fiebre Reumática
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Cardiopatía Reumática
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Lidocaína
Límite:
Humans
Idioma:
En
Revista:
The Philippine Children’s Medical Center Journal
Año:
2018
Tipo del documento:
Article