Basic studies on the anthelmintic action of dymanthine (Thelmesan)
Acta Medica Philippina
; : 0-2.
Article
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| ID: wpr-959464
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WPRO
ABSTRACT
In vitro test to assess the anthelmintic efficacy of a new synthetic compounds. Dymanthine, were made utilizing human Ascaris lumbricoides as test objects. The results obtained show that: 1) concentrations from 1:1000 to 1:500, or greater, produce paralysis and subsequent death of the worm in about three hours or more2) Lesser amount up to 1:2000 result in moderate to severe depression of the ascarids; 3) Cuticular absorption mechanisms appear to be involved appreciably in the anthelmintic action of the compound and4) Dymanthine, like Piperazine, consistently deminishes the contractible response to Acetylcholine of ascaris nerve-muscle preparationsEvidences strongly suggest that the above pharmacologic agents produce inhibition of ascaris activity through a similar manner of action, that is myoneural blockade. (Summary)
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Base de datos:
WPRIM
Idioma:
En
Revista:
Acta Medica Philippina
Año:
2000
Tipo del documento:
Article