Progress in signaling pathways related to the fibrosis mechanism in systemic sclerosis / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
; (12): 824-830, 2022.
Article
en Zh
| WPRIM
| ID: wpr-958263
Biblioteca responsable:
WPRO
ABSTRACT
Systemic sclerosis (SSc) is a complex and chronic autoimmune disease causing fibrosis in multiple tissues and organs. The cause of fibrosis may be related to the production of extracellular matrix (ECM) such as type Ⅰ and Ⅲ collagens, elastin and fibronectin resulting from the transformation of activated fibroblasts (FB) into muscle-forming fibroblasts (MFB). ECM could seriously damage the skin, lung, heart, kidney and other organs. At present, many studies have shown that several signaling pathways including TGF-β, mTOR, JAK/STAT, Wnt/β-Catenin, Hedgehog and Notch are involved in the proliferation of FB and the transformation of FB to MFB, which led to the production and deposition of a great quantity of ECM. Therefore, this article reviewed the relationship between these signaling pathways and fibrosis in SSc, hoping to provided reference for the development of effective treatments for SSc.
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1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Microbiology and Immunology
Año:
2022
Tipo del documento:
Article