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Therapeutic effects of estrogen-intervened EPCs transplantation on diabetic ischemic stroke rats / 药学实践与服务
Article en Zh | WPRIM | ID: wpr-953757
Biblioteca responsable: WPRO
ABSTRACT
Objective To explore the therapeutic effects of estrogen-intervened endothelial progenitor cells( EPCs) transplantation on diabetic ischemic stroke rats. Methods PKH26-labeled diabetic EPCs and estrogen-intervened diabetic EPCs were injected into rats via the tail vein 24 h after cerebral ischemia. Cerebral ischemic volume, behavioral changes, ischemic site vascularization and homing of EPCs were measured 3 d after EPCs injection. Results Compared with diabetic ischemic rats, estrogen-intervened EPCs transplantation had reduced infarct volumes, improved behavioral scores and ischemic site revascularization and promoted homing of EPCs to sites of injury(P<0.05). Conclusion Estrogen-intervened EPCs transplantation had a better therapeutic effect on diabetic ischemic stroke by promoting EPCs homing to injury site and EPCs-medicated neovascularization .
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Texto completo: 1 Base de datos: WPRIM Idioma: Zh Revista: Journal of Pharmaceutical Practice and Service Año: 2023 Tipo del documento: Article
Texto completo: 1 Base de datos: WPRIM Idioma: Zh Revista: Journal of Pharmaceutical Practice and Service Año: 2023 Tipo del documento: Article