Research progress of circular RNA in ocular fundus diseases / 中华眼底病杂志
Chinese Journal of Ocular Fundus Diseases
; (6): 334-339, 2022.
Article
en Zh
| WPRIM
| ID: wpr-934314
Biblioteca responsable:
WPRO
ABSTRACT
Circular RNA (circRNA) is a new group of endogenous non-coding RNAs produced by back-splicing, which has multiple molecular functions such as acting as microRNA sponges, regulators of transcription and splicing, adaptors for protein-protein interaction. Recent studies have shown that circRNA play an essential role in development and progression of retinal microvascular dysfunction, diabetic retinopathy, age-related macular degeneration, proliferative vitreoretinopathy, eye diseases caused by hyperhomocysteine and ocular malignancy. In pathological conditions, the differential expression of circRNA alters the transcription and translation of corresponding genes, thus changing the activity and function of cells. CircRNA may become a new marker and prognostic indicator of fundus diseases, and its targeted intervention may also become a potential treatment for fundus diseases.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Ocular Fundus Diseases
Año:
2022
Tipo del documento:
Article