Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options / 浙江大学学报（英文版）（B辑：生物医学和生物技术）
J. Zhejiang Univ., Sci. B (Internet)
; (12): 265-285, 2022.
Article
en En
| WPRIM
| ID: wpr-929058
Biblioteca responsable:
WPRO
ABSTRACT
Acetaminophen, also known as N-acetyl-p-aminophenol (APAP), is commonly used as an antipyretic and analgesic agent. APAP overdose can induce hepatic toxicity, known as acetaminophen-induced liver injury (AILI). However, therapeutic doses of APAP can also induce AILI in patients with excessive alcohol intake or who are fasting. Hence, there is a need to understand the potential pathological mechanisms underlying AILI. In this review, we summarize three main mechanisms involved in the pathogenesis of AILI: hepatocyte necrosis, sterile inflammation, and hepatocyte regeneration. The relevant factors are elucidated and discussed. For instance, N-acetyl-p-benzoquinone imine (NAPQI) protein adducts trigger mitochondrial oxidative/nitrosative stress during hepatocyte necrosis, danger-associated molecular patterns (DAMPs) are released to elicit sterile inflammation, and certain growth factors contribute to liver regeneration. Finally, we describe the current potential treatment options for AILI patients and promising novel strategies available to researchers and pharmacists. This review provides a clearer understanding of AILI-related mechanisms to guide drug screening and selection for the clinical treatment of AILI patients in the future.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Analgésicos no Narcóticos
/
Enfermedad Hepática Inducida por Sustancias y Drogas
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Enfermedad Hepática Crónica Inducida por Sustancias y Drogas
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Inflamación
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Hígado
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Acetaminofén
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Ratones Endogámicos C57BL
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Necrosis
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J. Zhejiang Univ., Sci. B (Internet)
Año:
2022
Tipo del documento:
Article