Clinical Diagnosis and Prenatal Screening of Hb Lepore-BW Associated with IVS-II-654 Heterozygous Mutation / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 529-533, 2022.
Article
en Zh
| WPRIM
| ID: wpr-928748
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To identify one case of rare Hb Lepore-BW associated with IVS-II-654 heterozygous mutation in Sichuan area.@*METHODS@#The blood routine examination and hemoglobin electrophoresis methods were used to analyze the blood routine parameters, HbA2 and HbF in the samples of peripheral blood in proband and his parents, as well as the cord blood of pregnant woman. The detection of thalassemia gene and Sanger sequencing methods were used to detect the hemoglobin mutations.@*RESULTS@#The result showed that the Hb Lepore-BW heterozygous mutation was detected in the father of the proband, while a rare Hb Lepore-BW with IVS-II-654 heterozygous mutation was detected in the proband, as well as his mother and cord blood were both detected as IVS-II-654 heterozygous mutation.@*CONCLUSION@#The study identified a rare Hb Lepore-BW with IVS-II-654 heterozygous mutation, which was characterized by intermediate β-thalassemia. It is necessary to hemoglobin electrophoresis combined with routine blood testing in prenatal screening.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Diagnóstico Prenatal
/
Hemoglobinas Anormales
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Talasemia beta
/
Heterocigoto
/
Mutación
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Female
/
Humans
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Male
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Newborn
/
Pregnancy
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2022
Tipo del documento:
Article