A new phloroglucinol from Dryopteris fragrans and its antibacterial activity in vitro / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 2474-2479, 2022.
Article
en Zh
| WPRIM
| ID: wpr-928127
Biblioteca responsable:
WPRO
ABSTRACT
A new phloroglucinol was isolated from 50% ethanol extract of Dryopteris fragrans by silica gel column chromatography, Sephadex LH-20 gel column chromatography, thin-layer chromatography(TLC), and preparative liquid column chromatography. On the basis of MS, ~1H-NMR, ~(13)C-NMR, and reference materials, compound 1 was identified as 2,5-cyclohexadien-1-one, 2-{[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-isobutyl)phenyl]methyl}-3,5-dihydroxy-4,4-dimethyl-6-(1-oxobutyl)(1), and named disaspidin BB. Compound 1 was evaluated for its antibacterial activity. The experimental results showed that compared with the commonly used topical antibiotics erythromycin or mupirocin, disaspidin BB exhibited significant antibacterial activities against Staphylococcus epidermidis(SEP), S. haemolyticus(SHA), and methicillin-resistant S. aureus(MRSA)(P<0.05). Additionally, disaspidin BB was sensitive to ceftazidime-resistant SEP1-SEP4, SHA5-SHA7, MRSA8, and MRSA9. The MIC values of disaspidin BB against SEP and SHA were 1.67-2.71 μg·mL~(-1) and 10.00-33.33 μg·mL~(-1) respectively. Disaspidin BB has good antibacterial activities and deserves development as a new anti-infective drug for external use.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Floroglucinol
/
Extractos Vegetales
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Pruebas de Sensibilidad Microbiana
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Dryopteris
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Staphylococcus aureus Resistente a Meticilina
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Antibacterianos
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Año:
2022
Tipo del documento:
Article