Aberrant Expression and Glycosylation of Mucins in Gastric Mucosal Disease / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 294-298, 2022.
Article
en Zh
| WPRIM
| ID: wpr-927878
Biblioteca responsable:
WPRO
ABSTRACT
Mucins,a family of heavily glycosylated proteins,present mainly in epithelial cells.They function as essential barriers for epithelium and play important roles in cellular physiological processes.Aberrant expression and glycosylation of mucins in gastric epithelium occur at pathological conditions,such as Helicobacter pylori infection,chronic atrophic gastritis,intestinal metastasis,dysplasia,and gastric cancer.This review addresses the major roles played by mucins and associated O-glycan structures in normal gastric epithelium.Further,we expound the alterations of expression patterns and glycan signatures of mucins at those pathological conditions.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Neoplasias Gástricas
/
Glicosilación
/
Helicobacter pylori
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Infecciones por Helicobacter
/
Mucosa Gástrica
/
Mucinas
Límite:
Humans
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Año:
2022
Tipo del documento:
Article