Abnormal neurobiochemical metabolites in the first / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 1090-1095, 2021.
Article
en En
| WPRIM
| ID: wpr-922588
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVES@#To explore the metabolite characteristics in medial prefrontal cortex (mPFC) by @*METHODS@#A total of 46 patients with the first-episode schizophrenia (FES), 49 people with clinical high risk (CHR), 61 people with genetic high risk (GHR), and 58 healthy controls (HC) were enrolled. The levels of N-acetylaspartylglutamate+N-acetylaspartate (tNAA), choline-containing compounds (Cho) and myo-inositol (MI), glutamate+glutamine (Glx) in medial prefrontal cortex were measured by single-voxel @*RESULTS@#There were significant differences in Glx, tNAA, and MI concentrations among 4 groups (all @*CONCLUSIONS@#The decreased levels of MI and Glx in the FES patients suggest that there may be glial functional damage and glutamatergic transmitter dysfunction in the early stage of the disease. The compensatory increase of metabolites may be a protective factor for schizophrenia in the genetic individuals.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Esquizofrenia
/
Imagen por Resonancia Magnética
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Espectroscopía de Resonancia Magnética
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Ácido Aspártico
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Ácido Glutámico
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Espectroscopía de Protones por Resonancia Magnética
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Glutamina
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Journal of Central South University(Medical Sciences)
Año:
2021
Tipo del documento:
Article