Factors Defining the Development of Severe Illness in Patients with COVID-19: A Retrospective Study / 生物医学与环境科学（英文）
Biomedical and Environmental Sciences
; (12): 984-991, 2021.
Article
en En
| WPRIM
| ID: wpr-921356
Biblioteca responsable:
WPRO
ABSTRACT
Objective@#Early triage of patients with coronavirus disease 2019 (COVID-19) is pivotal in managing the disease. However, studies on the clinical risk score system of the risk factors for the development of severe disease are limited. Hence, we conducted a clinical risk score system for severe illness, which might optimize appropriate treatment strategies.@*Methods@#We conducted a retrospective, single-center study at the JinYinTan Hospital from January 24, 2020 to March 31, 2020. We evaluated the demographic, clinical, and laboratory data and performed a 10-fold cross-validation to split the data into a training set and validation set. We then screened the prognostic factors for severe illness using the least absolute shrinkage and selection operator (LASSO) and logistic regression, and finally conducted a risk score to estimate the probability of severe illness in the training set. Data from the validation set were used to validate the score.@*Results@#A total of 295 patients were included. From 49 potential risk factors, 3 variables were measured as the risk score: neutrophil to lymphocyte ratio ( @*Conclusion@#This report may help define the potential of developing severe illness in patients with COVID-19 at an early stage, which might be related to the neutrophil to lymphocyte ratio, albumin, and chest computed tomography abnormalities.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Índice de Severidad de la Enfermedad
/
Estudios Retrospectivos
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Medición de Riesgo
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Nomogramas
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COVID-19
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Biomedical and Environmental Sciences
Año:
2021
Tipo del documento:
Article