Identification of rare coding variants associated with Kawasaki disease by whole exome sequencing
Genomics & Informatics
; : e38-2021.
Article
en En
| WPRIM
| ID: wpr-914330
Biblioteca responsable:
WPRO
ABSTRACT
Kawasaki disease (KD) is an acute pediatric vasculitis that affects genetically susceptible infants and children. To identify coding variants that influence susceptibility to KD, we conducted whole exome sequencing of 159 patients with KD and 902 controls, and performed a replication study in an independent 586 cases and 732 controls. We identified five rare coding variants in five genes (FCRLA, PTGER4, IL17F, CARD11, and SIGLEC10) associated with KD (odds ratio [OR], 1.18–4.41; p = 0.0027–0.031). We also performed association analysis in 26 KD patients with coronary artery aneurysms (CAAs; diameter > 5 mm) and 124 patients without CAAs (diameter < 3 mm), and identified another five rare coding variants in five genes (FGFR4, IL31RA, FNDC1, MMP8, and FOXN1), which may be associated with CAA (OR, 3.89–37.3; p = 0.0058–0.0261). These results provide insights into new candidate genes and genetic variants potentially involved in the development of KD and CAA.
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1
Base de datos:
WPRIM
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Genomics & Informatics
Año:
2021
Tipo del documento:
Article