Advance in Genetic Mechanism of Primary Progressive Aphasia (review) / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
; (12): 1305-1310, 2020.
Article
en Zh
| WPRIM
| ID: wpr-905370
Biblioteca responsable:
WPRO
ABSTRACT
Primary progressive aphasia (PPA) is a common neurodegenerative speech disease. Earlier studies on PPA merely observed preliminary pathogenic factors at the brain level. Based on genetic technology, almost 20% to 30% patients with autosomal dominant inheritance reveals that this deficit is closely relevant to gene mutation. C9 gene mutation is the primary factor related to amyotrophic lateral sclerosis and frontotemporal dementia, which is attributed to the main causes of PPA. Repeating expansion of C9 gene may influence the expression of C9 gene, block the combination of RNA and protein, and destroy RNA function.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Rehabilitation Theory and Practice
Año:
2020
Tipo del documento:
Article