Downregulation of Reactive Oxygen Species in Apoptosis
Journal of Cancer Prevention
; : 13-20, 2016.
Article
en En
| WPRIM
| ID: wpr-89896
Biblioteca responsable:
WPRO
ABSTRACT
Generation of reactive oxygen species (ROS) by diverse anti-cancer drugs or phytochemicals has been closely related with the induction of apoptosis in cancers. Also, the downregulation of ROS by these chemicals has been found to block initiation of carcinogenesis. Therefore, modulation of ROS by phytochemicals emerges as a crucial mechanism to regulate apoptosis in cancer prevention or therapy. This review summarizes the current understanding of the selected chemical compounds and related cellular components that modulate ROS during apoptotic process. Metformin, quercetin, curcumin, vitamin C, and other compounds have been shown to downregulate ROS in the cellular apoptotic process, and some of them even induce apoptosis in cancer cells. The cellular components mediating the downregulation of ROS include nuclear factor erythroid 2-related factor 2 antioxidant signaling pathway, thioredoxin, catalase, glutathione, heme oxygenase-1, and uncoupling proteins. The present review provides information on the relationship between these compounds and the cellular components in modulating ROS in apoptotic cancer cells.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Ácido Ascórbico
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Quercetina
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Tiorredoxinas
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Catalasa
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Regulación hacia Abajo
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Negociación
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Especies Reactivas de Oxígeno
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Apoptosis
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Curcumina
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Hemo-Oxigenasa 1
Idioma:
En
Revista:
Journal of Cancer Prevention
Año:
2016
Tipo del documento:
Article