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Urinary Free Metanephrines for Diagnosis of Pheochromocytoma and Paraganglioma
Article en En | WPRIM | ID: wpr-890523
Biblioteca responsable: WPRO
ABSTRACT
Background@#Pheochromocytoma and paraganglioma (PPGL) is diagnosed through biochemical confirmation of excessive catecholamines in urine and plasma. Recent technological developments have allowed us to measure urinary free metanephrines; however, the diagnostic accuracy of these new methods and the diagnostic cutoff values have not been evaluated. @*Methods@#This is a retrospective study of 595 subjects, including 71 PPGL cases and 524 controls. PPGL was based on pathological confirmation. Subjects with no evidence of PPGL over 2 years were included in the control group. @*Results@#Urinary free metanephrines yielded similar area under the curve (AUC) to urinary fractionated metanephrines and plasma free metanephrines. However, urinary free normetanephrine yielded a better AUC than did urinary fractionated normetanephrine. The optimal cutoff for urinary free metanephrine and normetanephrine corrected for urinary creatinine yielded 97.2% sensitivity and 98.1% specificity. @*Conclusion@#Urinary free metanephrines are a reliable method for diagnosing PPGL in Asian populations compared with existing biochemical methods.
Texto completo: 1 Base de datos: WPRIM Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Idioma: En Revista: Endocrinology and Metabolism Año: 2021 Tipo del documento: Article
Texto completo: 1 Base de datos: WPRIM Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Idioma: En Revista: Endocrinology and Metabolism Año: 2021 Tipo del documento: Article