Secondary metabolites of endophyte Alternaria sp. W-1 from Laminaria japonica / 药学学报
Acta Pharmaceutica Sinica
; (12): 2248-2251, 2021.
Article
en Zh
| WPRIM
| ID: wpr-887051
Biblioteca responsable:
WPRO
ABSTRACT
Six compounds were isolated from the crude extract of the liquid culture of Alternaria sp. W-1 by silica gel column chromatography, Sephadex LH-20 gel column chromatography, and HPLC. They were identified as 6-iso-tricycloalternarene 6a (1), tricycloalternarene 6a (2), tricycloalternarene B (3), uracil (4), 5-methyluracil (5), and lumichrome (6) through HR-MS, NMR and literature comparison. 6-iso-Tricycloalternarene 6a (1) is a new compound which has never been reported in the literature. In cytotoxicity assay, compounds 1-3 showed weak inhibition activity to human hepatoma cell line SMMC-7721 and human gastric cell line SGC-7901.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2021
Tipo del documento:
Article