Hypoxia-degradable and long-circulating zwitterionic phosphorylcholine-based nanogel for enhanced tumor drug delivery
Acta Pharmaceutica Sinica B
; (6): 560-571, 2021.
Article
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| WPRIM
| ID: wpr-881154
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WPRO
ABSTRACT
Tumor microenvironment has been widely utilized for advanced drug delivery in recent years, among which hypoxia-responsive drug delivery systems have become the research hotspot. Although hypoxia-responsive micelles or polymersomes have been successfully developed, a type of hypoxia-degradable nanogel has rarely been reported and the advantages of hypoxia-degradable nanogel over other kinds of degradable nanogels in tumor drug delivery remain unclear. Herein, we reported the synthesis of a novel hypoxia-responsive crosslinker and the fabrication of a hypoxia-degradable zwitterionic poly(phosphorylcholine)-based (
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WPRIM
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En
Revista:
Acta Pharmaceutica Sinica B
Año:
2021
Tipo del documento:
Article