Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain: involvement of histone deacetylase inhibition / 医学前沿
Frontiers of Medicine
; (4): 79-90, 2021.
Article
en En
| WPRIM
| ID: wpr-880969
Biblioteca responsable:
WPRO
ABSTRACT
Natural killer (NK) cells, a type of cytotoxic lymphocytes, can infiltrate into ischemic brain and exacerbate neuronal cell death. Astragaloside IV (ASIV) is the major bioactive ingredient of Astragalus membranaceus, a Chinese herbal medicine, and possesses potent immunomodulatory and neuroprotective properties. This study investigated the effects of ASIV on post-ischemic brain infiltration and activation of NK cells. ASIV reduced brain infarction and alleviated functional deficits in MCAO rats, and these beneficial effects persisted for at least 7 days. Abundant NK cells infiltrated into the ischemic hemisphere on day 1 after brain ischemia, and this infiltration was suppressed by ASIV. Strikingly, ASIV reversed NK cell deficiency in the spleen and blood after brain ischemia. ASIV inhibited astrocyte-derived CCL2 upregulation and reduced CCR2
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Saponinas
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Triterpenos
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Encéfalo
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Células Asesinas Naturales
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Histona Desacetilasas
Límite:
Animals
Idioma:
En
Revista:
Frontiers of Medicine
Año:
2021
Tipo del documento:
Article