Protective effect of iridoid glycosides of radix scrophulariae on endoplasmic reticulum stress induced by oxygen-glucose deprivation and reperfusion / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 705-713, 2020.
Article
en Zh
| WPRIM
| ID: wpr-879932
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the regulatory effect of iridoid glycoside of radix scrophulariae (IGRS) on endoplasmic reticulum stress induced by oxygen-glucose deprivation and reperfusion @*METHODS@#Rat pheochromocytoma PC12 cells were pretreated with IGRS (50, 100, 200 μg/mL) for 24h, and the @*RESULTS@#The damage caused by OGD/R to PC12 cells was significantly reduced by IGRS, with significant effect on increasing survival rate and reducing LDH release (all @*CONCLUSIONS@#IGRS has neuroprotective effect, which may alleviate cerebral ischemia-reperfusion injury by regulating SERCA2, maintaining calcium balance, and inhibiting endoplasmic reticulum stress-mediated apoptosis.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Oxígeno
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Caracoles
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Técnicas In Vitro
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Reperfusión
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Daño por Reperfusión
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Regulación hacia Abajo
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Supervivencia Celular
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Células PC12
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Glicósidos Iridoides
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Estrés del Retículo Endoplásmico
Límite:
Animals
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2020
Tipo del documento:
Article