Effects of antihyperglycemics on endothelial progenitor cells / 浙江大学学报·医学版
Zhejiang Daxue xuebao. Yixue ban
; (6): 629-636, 2020.
Article
en Zh
| WPRIM
| ID: wpr-879924
Biblioteca responsable:
WPRO
ABSTRACT
Endothelial progenitor cells (EPCs) play an important role in diabetic vascular complications. A large number of studies have revealed that some clinical antihyperglycemics can improve the complications of diabetes by regulating the function of EPCs. Metformin can improve EPCs function in diabetic patients by regulating oxidative stress level or downstream signaling pathway of adenosine monophosphate activated protein kinase; Pioglitazone can delay the aging of EPCs by regulating telomerase activity; acarbose, sitagliptin and insulin can promote the proliferation, migration and adhesion of EPCs. In addition to lowering blood glucose, the effects of antihyperglycemics on EPCs may also be one of the mechanisms to improve the complications of diabetes. This article reviews the research progress on the regulation of EPC proliferation and function by antihyperglycemics.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Transducción de Señal
/
Movimiento Celular
/
Células Cultivadas
/
Células Progenitoras Endoteliales
/
Hipoglucemiantes
Límite:
Humans
Idioma:
Zh
Revista:
Zhejiang Daxue xuebao. Yixue ban
Año:
2020
Tipo del documento:
Article