Status of content analysis of pyrrolizidine alkaloids in food and herbs / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 5421-5428, 2020.
Article
en Zh
| WPRIM
| ID: wpr-878776
Biblioteca responsable:
WPRO
ABSTRACT
Pyrrolizidine alkaloids(PAs) are a group of naturally occurring alkaloids with a pyrrolizidine skeleton which can be found in about 3% of the world's flowering plants. It is notorious that PAs are cause the hepatoxic and genotoxic-carcinogenic effects by taking PA-containing herbs, food and dietary supplements. In order to control the poisoning caused by PAs, European Medicines Agency has set a limit of intake of PAs from herbal medicinal products at 0.007 μg of 1,2-unsaturated PAs/kg body weight. Nonetheless, a systematic overview of the amount of PAs in the herb has not been provided. Therefore, this paper is to systematically review the current status of PAs content analysis of herbal medicines and foods reported in the literature, and to provide theoretical and experimental support for the safety risk assessment and control of PAs in Chinese herbal medicines.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Plantas Medicinales
/
Alcaloides de Pirrolicidina
/
Medicina de Hierbas
/
Alimentos
/
Fitoterapia
Tipo de estudio:
Systematic_reviews
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Año:
2020
Tipo del documento:
Article