Processing Study of Epimedium Flavonoids Self-Assembled Micelles Fried with Suet Oil on Its Bioavailability / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 726-730, 2017.
Article
en Zh
| WPRIM
| ID: wpr-858719
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE: To study the influence of bioavailability of Epimedium flavonoids after processing by suet oil. METHODS: Pharmacokinetics parameters of rats Epimedium flavonoids and icariin and baohuoside I was determining by the method of pharmacology effect and plasma concentration method. RESULTS: The concentration of the Epimedium flavonoids, icariin and baohuoside I in micelles groups were higher than that of the active pharmaceutical ingredient(API). ρmax were increased by 77.94%, 38.99% and 49.90%; AUC0-t increased by 95.19%, 37.76% and 43.49%; AUC0-∞ increased by 119.35%, 35.37% and 46.26% on Epimedium flavonoids, icariin and baohuoside I group. CONCLUSION: Suet oil improved the bioavailability of Epimedium flavonoids and promoted its absorption.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmaceutical Journal
Año:
2017
Tipo del documento:
Article