Study on tripterin sustained-release dropping pills / 中草药
Zhongcaoyao
; Zhongcaoyao;(24): 834-838, 2013.
Article
en Zh
| WPRIM
| ID: wpr-855409
Biblioteca responsable:
WPRO
ABSTRACT
Objective: To prepare the Tripterin Sustained-release Dropping Pills (TSRDPs), investigate the disperse state and in vitro release, and optimize the preparation technology. Methods: The TSRDPs were prepared by solid dispersion method with PEG 4000 and glycerol monostearate (GM) as carrier materials. Orthogonal design was conducted to explore the influencing factors of the preparation technology by evaluating the indexes of roundness and weight difference. Results: The ideal condition of TSRDPs: the ratio of tripterin-GM-PEG 4000 was 1:3:7; the temperature of drug mixture was 80 °C; dropping speed was 20 d/min; dropping distance was 5 cm; and the condensate temperature was 15 °C. Tripterin existed as amorphous state in carriers. The maximum cumulative release amount of tripterin was 91.2% at 12 h. Conclusion: The prepared TSRDPs have a good sustained-release effect.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Zhongcaoyao
Año:
2013
Tipo del documento:
Article