Attenuated Renal Excretion in Response to Thiazide Diuretics in Gitelman's Syndrome: A Case Report
Journal of Korean Medical Science
; : 567-570, 2002.
Article
en En
| WPRIM
| ID: wpr-83846
Biblioteca responsable:
WPRO
ABSTRACT
Gitelman's syndrome is a variant of Bartter's syndrome characterized by hypocalciuria and hypomagnesemia. The administration of thiazide diuretics may induce a subnormal increase of urinary Na+ and Cl- excretion in patients with Gitelman's syndrome, consistent with the hypothesis that less Na+ and Cl- than normal is reabsorbed by the thiazide-inhibitable transporter in Gitelman's syndrome. Specific mutations of NaCl cotransporter, coupled with mutant NaCl cotransporter expression studies clearly demonstrated that many of the characteristics of individuals with Gitelman's syndrome are explained by lack of function of NaCl cotransporter. We recently diagnosed a patient with Gitelman's syndrome by performing the thiazide and furosemide tests, and it is suggested that the clearance studies by diuretic administration may be of diagnostic help in Gitelman's syndrome.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Sodio
/
Síndrome
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Síndrome de Bartter
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Benzotiadiazinas
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Cloruros
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Simportadores
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Diuréticos
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Electrólitos
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Simportadores del Cloruro de Sodio
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Inhibidores de los Simportadores del Cloruro de Sodio
Límite:
Adolescent
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Female
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Humans
Idioma:
En
Revista:
Journal of Korean Medical Science
Año:
2002
Tipo del documento:
Article