How Well Does the Target INR Level Maintain in Warfarin-Treated Patients with Non-ValvularAtrial Fibrillation?
Yonsei Medical Journal
; : 83-88, 2009.
Article
en En
| WPRIM
| ID: wpr-83527
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: Although warfarin is an effective oral anticoagulation (OAC) drug to reduce the risk of thromboembolism in patients with non-valvular atrial fibrillation (NVAF), long term follow-up data are scarce to be certain whether the target INR level is maintained in warfarin-treated patients in Korea. The aim of this study was to evaluate how well INRs are maintained within the target range using a new index, INR stability (= 100 x number of INRs within target range/total number of INR measurements) which we made, and to find out any correlation between thromboembolic events and INR stability. MATERIALS AND METHODS: This study was an observational analysis of retrospectively collected data of 129 patients with NVAF from April 2000 to December 2005 at a single tertiary hospital. All patients were registered at the anticoagulation service. RESULTS: The median duration of follow up was 2.03 years (interquartile range 1.35 - 2.96). During the follow-up period, 60.9 +/- 14.9% of the INR were within the target INR range. INR stability was not significantly different between patients without and with stroke (61.2 +/- 15.0% vs 53.3 +/- 4.9%). Among the known factors affecting fluctuations of the INR value, the most frequent factor was noncompliance (41.8%). CONCLUSION: The present study showed that it was not enough to maintain INR values within the target range in warfarin-treated patients with NVAF even at a tertiary hospital. Noncompliance is an important problem which interferes with maintaining target INR range.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fibrilación Atrial
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Trombosis
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Warfarina
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Estudios Retrospectivos
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Factores de Riesgo
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Estudios de Seguimiento
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Factores de Edad
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Cooperación del Paciente
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Monitoreo de Drogas
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Relación Normalizada Internacional
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Yonsei Medical Journal
Año:
2009
Tipo del documento:
Article