Relation between K469E gene polymorphism of ICAM-1 and recurrence of ACS and cardiovascular mortality
Asian Pacific Journal of Tropical Medicine
; (12): 916-920, 2013.
Article
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| ID: wpr-819755
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To explore the relation between K469E gene polymorphism of intercellular adhesion molecular-1 (ICAM-1) and the recurrence of ACS and cardiovascular mortality.@*METHODS@#A total of 185 patients with ACS hospitalized in Department of Cardiology in our hospital from Sep 2007 to Sep 2008 were selected as objectives. Polymerase chain reaction was used to analyze K469E gene polymorphism of ICAM-1. According to the genotypes, they were divided into two groups: group with K allele (KK+KE) and group without K allele (EE). The two groups were followed up prospectively for five years and blood lipid, blood pressure, blood glucose, recurrence and death of ACS were collected when the patients left hospital. The relation between ICAM-1 gene polymorphism and the recurrence of ACS and cardiovascular mortality was analyzed by Logistic regression.@*RESULTS@#After long-term follow-up, it was found that ACS recurred on 71 cases (38.4%) and 10 cases died, among which 3 cases died of cardiovascular disease. The recurrence of ACS and cardiovascular mortality in group with K allele were remarkably higher than that in group without K allele (P0.05).@*CONCLUSIONS@#K469E gene polymorphism of ICAM-1 was related to ACS recurrence and cardiovascular mortality, K allele probably an independent risky factor and hypertension and to which the level of HDL-C were closely related.
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Base de datos:
WPRIM
Asunto principal:
Sangre
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Glucemia
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Presión Sanguínea
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Modelos Logísticos
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China
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Epidemiología
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Estudios Prospectivos
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Factores de Riesgo
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Estudios de Seguimiento
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Mortalidad
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2013
Tipo del documento:
Article