Antiulcer activity of methanolic extract and fractions of Picralima nitida seeds(Apocynacaea) in rats
Asian Pacific Journal of Tropical Medicine
; (12): 13-15, 2011.
Article
en En
| WPRIM
| ID: wpr-819570
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To investigated the antisecrectory activities of the methanol extract, chloroform fraction and methanol fraction of Picralima nitida seeds.@*METHODS@#The methanol extract of Picralima nitida seeds was fractionated into chloroform fraction and methanol fraction. They were evaluated for antiulcer activity and gastric emptying time in rats using aspirin-pylorus-ligation model.@*RESULTS@#Oral administration of the methanol extract, chloroform fraction and methanol fraction at 1 000 mg/kg reduced gastric ulcer by 56.4%, 40.0% and 56.3%, respectively; and the fractions of the extract significantly (P<0.05) reduced gastric emptying time when compared to the control. Gastric acidity was significantly decreased when compared with saline group, 40.25 mEq/L in methanol extract, 50.0 mEq/L in chloroform fraction 51.25 mEq/L in methanol fraction but had no significant effect on the gastric secretion volume.@*CONCLUSIONS@#These findings showed that methanol extract, chloroform fraction and methanol fraction of the seeds of Picralima possessed potent antiulcer properties and some antisecretory properties.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
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Semillas
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Factores de Tiempo
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Extractos Vegetales
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Química
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Tamizaje Masivo
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Administración Oral
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Resultado del Tratamiento
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Apocynaceae
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Determinación de la Acidez Gástrica
Tipo de estudio:
Prognostic_studies
/
Screening_studies
Límite:
Animals
Idioma:
En
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2011
Tipo del documento:
Article